KPV

About

KPV (lysine-proline-valine) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (alpha-MSH), a melanocortin hormone produced in the pituitary that regulates energy balance and has documented immunomodulating and anti-inflammatory effects. Research has explored KPV's anti-inflammatory action - which it appears to exert by directly influencing inflammatory signaling - along with antimicrobial and wound-healing effects. Most evidence is from laboratory and animal studies, with limited human data.

Research Applications

• Inflammation reduction
• Antimicrobial activity
• Wound healing, including burns and skin damage
• Gut and colon health

Mechanism of Action

KPV is the active C-terminal fragment of alpha-MSH and appears to influence inflammatory processes directly within cells, contributing to its reported anti-inflammatory and antimicrobial effects.

Molecular Info

Class

Peptide

Structure

Tripeptide (lysine-proline-valine); C-terminal fragment of alpha-MSH (11-13)

Related compound

Alpha-melanocyte-stimulating hormone (alpha-MSH)

Primary research areas

Inflammation, antimicrobial activity, and wound healing

Dosing Guidance

Range

KPV appears most often in reconstitution-focused reference material, and specific research amounts vary by context.

Frequency

Frequency varies across research contexts and is presented here as educational background only.

Timing

Timing is not consistently defined across the available research references.

Cycle length

Cycle length is not consistently defined across the available research references.

Notes

These details are educational context only. Protocol values are examples and should not be treated as medical instructions.

Known Risks

• Reported effects include brain fog, orange skin pigment, skin irritation, and gastrointestinal upset
• Not recommended for subjects who are nursing or pregnant

Regulatory & Evidence Status

Evidence level

Limited human trial evidence; most findings come from animal or laboratory studies, and the safety profile is not well characterized in humans.

FDA status

Not approved for therapeutic use.