Ipamorelin

About

Ipamorelin is a synthetic pentapeptide classified as a growth hormone-releasing peptide. It stimulates the release of growth hormone (GH) by mimicking ghrelin, and is noted for being selective - unlike many secretagogues, it is described as not strongly activating the body's stress-hormone response. Research on ipamorelin is limited, and definitive information on side effects and optimal dosing is lacking.

Research Applications

• Growth-hormone release
• Muscle growth and body composition
• Injury recovery
• Anti-aging

Mechanism of Action

Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist that binds ghrelin receptors, stimulates the release of somatocrinin (GHRH), and inhibits somatostatin.

Molecular Info

Class

Peptide

Structure

Pentapeptide (five amino acids)

Target

Ghrelin / growth hormone secretagogue receptor

Primary research areas

Growth hormone release, muscle growth, and recovery

Dosing Guidance

Range

Research discussions cite roughly 200-300 mcg per day, beginning at the lowest amount and titrating as needed.

Frequency

Research discussions describe daily injection.

Timing

Timing is not consistently defined across the available research references.

Cycle length

Research discussions describe cycles of roughly 8-12 weeks followed by about 4 weeks off.

Notes

These details are educational context only. Protocol values are examples and should not be treated as medical instructions.

Regulatory & Evidence Status

Evidence level

Did not complete clinical development; limited published research on side effects and dosing.

FDA status

Not approved; did not complete clinical development.

WADA status

Prohibited.

Standard Ipamorelin Protocol

Example calculation values using a 5 mg vial, 2 mL bacteriostatic water, and a 300 mcg target amount.

Vial

5 mg

Water

2 mL

Target

300 mcg

Syringe

U-100 · 100 units

These example values cover reconstitution math only; scheduling, route, and administration decisions are not included.