BPC-157
Body Protection Compound 157
About
BPC-157 is a 15-amino-acid peptide related to body protection compound, a peptide described in gastric juices. Research has explored its role in gastrointestinal tissue protection, angiogenesis, musculoskeletal soft-tissue healing, neuroprotection, and vascular responses. Most findings are from laboratory or animal studies, with limited human evidence available.
Research Applications
- Musculoskeletal soft-tissue healing
- Tendon fibroblast and growth-receptor expression
- Neuroprotection and gut-brain-axis signaling
- Vascular tone and nitric-oxide pathways
- Gastrointestinal protection and fistula healing
Mechanism of Action
Research literature describes BPC-157 as interacting with vascular and repair pathways, including vascular endothelial growth factor signaling, fibroblast activity, collagen-related repair processes, and nitric-oxide-related vascular tone. These mechanisms remain research observations rather than established clinical claims.
Molecular Info
- Class
- Peptide
- Length
- 15 amino acids
- Sequence
- H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
- Primary research areas
- Gastrointestinal protection, soft-tissue repair, angiogenesis, and neuroprotection
Dosing Guidance
- Range
- Research references commonly discuss 250 mcg daily and 2–4 mcg/kg as a research rule-of-thumb.
- Frequency
- Frequency varies across research contexts and is presented here as educational background only.
- Timing
- Timing is not consistently defined across the available research references.
- Cycle length
- Cycle length is not consistently defined across the available research references.
- Notes
- These details are educational context only. Protocol values are examples and should not be treated as medical instructions.
Known Risks
- Potential side effects are not well characterized in humans
Regulatory & Evidence Status
- Evidence level
- Limited human data; most findings come from animal or laboratory studies, with few randomized controlled trials.
- FDA status
- Not approved as a drug.
- WADA status
- Prohibited (listed as of 2022).
Protocols
Example reconstitution math only. These are educational values, not medical instructions.
Conservative BPC-157 Protocol
Lower-amount example values using a 5 mg vial, 2 mL bacteriostatic water, and a 250 mcg target amount.
- Vial
- 5 mg
- Water
- 2 mL
- Target
- 250 mcg
- Syringe
- U-100 · 100 units
These example values cover reconstitution math only; scheduling, route, and administration decisions are not included.
Standard BPC-157 Protocol
Higher-amount example values using a 5 mg vial, 2 mL bacteriostatic water, and a 500 mcg target amount.
- Vial
- 5 mg
- Water
- 2 mL
- Target
- 500 mcg
- Syringe
- U-100 · 100 units
These example values cover reconstitution math only; scheduling, route, and administration decisions are not included.
References
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
Cell and Tissue Research · 2019 · Review
Reviewed BPC-157 research related to musculoskeletal soft-tissue healing and repair pathways.
DOI: 10.1007/s00441-019-03016-8
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
Molecules · 2014 · Cell study
Explored BPC-157 effects on growth hormone receptor expression in tendon fibroblast research.
DOI: 10.3390/molecules191119066
Pentadecapeptide BPC 157 and the central nervous system
Neural Regeneration Research · 2022 · Review
Discussed research involving BPC-157 and central-nervous-system pathways.
DOI: 10.4103/1673-5374.320969
Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway
Scientific Reports · 2020 · Preclinical study
Studied BPC-157 in relation to vascular tone and nitric-oxide-related signaling.
DOI: 10.1038/s41598-020-74022-y
Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy
Current Pharmaceutical Design · 2020 · Review
Reviewed research on BPC-157 in fistula-healing models and related tissue-repair contexts.
DOI: 10.2174/1381612826666200424180139
For research and educational purposes only. Not medical advice. Consult a qualified healthcare professional before using any peptide. All calculations should be independently verified.